???????? ??? ?? ???,
? ??? ????? ????? ?? ??? ???
¡ø??? ??? ?????? ?????? ???? ??
???????? ?????? ??? ?? ???? DBC1 ???? ??? ??? ??? ?????(super-enhancer)? ??? ??? ??? ?? ? ??? ?????? ?????? ???. ?? ?? ?? ?????? DBC1? ??? H3K4 ??? ??(KMT2D)? ??? H3 ???? ??(p300)? ???? ????? ?? ????? ??? ??? ??? ?????.
???? ?????? ??? ???? dynamics? ?????? ??? ?? ????. ??? ??? ??? ???? ?????? ???? ??? ???? ?????? ????? ? ?? ?? ???? ?? ??? ?? ???.
?? ??? ?? ???? DBC1? ?????? ???? ??? ??? ? ?? ?? ????? ?? ??????, ? ????? ??? ???? ???? ?????? ??? ?? DBC1? ??? ???? ?? Crispr/Cas9? ??? ??? ?? ??? ??? ???? ?? ??? ???? ??????? ?????? ???? ????? ?????.
???? DBC1? ?? ???? ????? ???? ??? ???? ?????? ???(??? H3 ???? ????? ???)? ??? ???? ????? ??? ??? ??? ????? ???? ?? ????? ????? ????? ??? ???. ?? DBC1? ???? ?? ? ?????? ?????? ?? ????? ??? ??? ?? ????.
?? ??? ????? ??? ???? ??? ???? ???? ??? ??? ?????? ???? DBC1? ??? ??? ??, ?? ??? ??? ?? ??????? Wnt ?????? DBC1? ?????? ??? ????? ????? ?????. ? DBC1? ?????? ??? KMT2D ? p300? ???? ????? ?????? ??????? ? ?? ?????? ?? ? ?? ????? ??? ?????? ??? ????.
??? ??? “? ??? ??? ???? ??? ??? ?? ???? ?? ?? ???? ???? ??? ?????? ???? ??? ??? ?? ??? ??”? “???? ??? ??? ???? DBC1? ?????? ?? ?????? ??? ? ?? ??? ????”? ???.
? ??? ??????? ???? ??????, ??? & ????? ?? ???? ???? ‘Nucleic Acids Research’ ??(Impact factor: 19.16)? 2022? 8? 12? ?????.
* DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300. Nucleic Acids Research, 2022 Aug 12, 50(14):7873-7888. DOI: (?1??: ???; ????: ???; ????:???, ???, ???)
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