???? ??? ?? ???,
???19? ??? ?? ?????
??????? ????(NSAIDs) ?? ?? ??
- ??????? ???? ???? ?? ?????? ???? ?? ?? ??
- ??? ?? ??? ???‘Clinical Infectious Diseases’?? ??
[??1] ???? ??? ??, ??? ???, ??? ???
???? ??? ?? ???(?? 1?? ???, ??? ???)? ???19? ??? ?? ????? ??????? ????(Non-steroidal anti-inflammatory drugs, ?? NSAIDs) ?? ??? ?? ???? ???? ?? ??? ????? ???.
?? 3?, ???19 ???? ???????? NSAIDs? ???? ?? ??? ??? ????? ???? ? ??? ??? ? ????? ??? ? ??. ???? ??? ???, ???19? ?????-???? 2(Angiotensin-converting enzyme 2, ?? ACE2)? ???? ??? ????? ?????, NSAIDs? ACE2 ??? ???? ? ??? ??? ??? ????.
??? ?? ?? ??? ??? ???? ???? ?? ?? FDA, EMA ? ?? ?? ??? ??????? ???19 ???? NSAIDs? ???? ?? ????? ????? ? ??? ??? ??. ??? ?? ??? ??? ????? ???? ???? ? ????? ???19 ????? NSAIDs? ??? ??? ??? ? ??.
?? ???? ????? ??? ?? ?????? ?????, ??? ????? ??????? ?? ???????? ??????, ?? 3? 27? ?????? ??????????? ??? ???19 ???? ???? ???? ? ??? ?????. ?? ????? ???? ??? ??????? ???? ???? ???19 ???? ???????(Real-World Data, RWD)??.
[??2] ????? ?? ??? ? ??????? ????(NSAIDs) ???? ?? ?????? ???? ??? ?? ?? ??
??, NSAIDs ???? ???? ?? ??? ? ?? ????????? ?? ??? ???? ???, ??, ??, ??????, ?????, ?????? ?? ?? ???? ??? ????? ???? ???? ??? ???? ??? ??? ?????.
?? ?? ??? ??? ??, ???19? ??? ?? ?? ? NSAIDs ???? ?? ?????? ??, ???? ??, ????? ??, ??? ?? ??? 1.54? ?? ?? ?????. ??, ???, ???, ??????? ??? ???? ???? ? ????? ?? ??? ?? ? ?? ?????.
? ??? ?? ?????? ???19 ??? ?? ?? ??? ??? ? ??? ????? ??-??? ??? ? NSAIDs? ??? ??????? ??? ??? ??? ? ??? ????.
???, ??? ???? “???19? ???? ?? ??? ?? ??? ?? ??? ??? ??? ? ?? ??? ??, ???? ???? ????? ???? ?? ? ?? ?? ????”? ???.
? ????? ??? ?? ??? ???? ‘Clinical Infectious Diseases(Impact Factor=8.313, JCR Ranking ?? 3.2%)’? 7.27(?) ??? ?????.
※ ???: Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study
※ ?? ??:
??
