???? ??? ?? ???, ??? ????? ??? ?? ??? ??
??? ? 40%? ???? ???? ???? ??? ?? ? ???? ?? ? ????, ?? ? ??? myokine?? ???? ????? ???? ?? ?? ? ??? ??? ?? ??? ??? ?? ? ??. ??, ????, ???? ??? ?? ???? ??? ???? ????, ????, ?????? ? ?? ?? ?????? ??? ? ??? ?????, ?? ?? ???? ?????.
????? ??? ??? ??? ?? ??? ?????. 2019? ??? ??? ???, ????? 65? ?? ??????? 2045?? 37%? ?? ??1? ??? ??? ??? ??? ????. ??? ???? ???(Sarcopenia)? 2016-2018?? ??, ?? ???? ???? ??????, ???? ??? ??? ???? ??? ??? ?????? ?????? ?????? ???? ???? ??. ??? ???? ??? mitochondria ?? ??, ??? ????, ????? ????? ?? ??? ???? ?? ??? ????? ??? ??.
???? ???? ??? ?? ?????? ?? ??? ???? ??? ??? ????? ????? ??? ???? ??? ??? ???? ??. ?? ? ?? ?????? ?????? ?? ??? ??? Journal of Cachexia, Sarcopenia and Muscle(impact factor 10.75)? 2? 27?(?) back to back?? ?????. ?? ???? ?? ??? Mount Sinai ????? DGIST ????? ???? ?????.
? ?? ??? ? ???? ??? ??? ?1??? ???? ??????? ????? ??? ???? ??? ?????. ???? ???? Cdon??? ???? ?????? ????? ????, ?? ? ????? ?? ? ??? ?? ??? ???? ??? ???? ???, ????? ???? ??? ??? ?? ???. ?? Cdon? ??????? ????? ???? FGF receptor? ??? ?? ??? ??? ??, ????? ????? ????? Cdon? ????? ????? ?? ?? ???. ??? ??? ?????? ???? ??????? ?????? ???? ???, Cdon? ??? ??? ? ???, Cdon? ?????? ??? ??? ??? ??? ??? ????.
[??1] Cdon? Pax7? ???? ??????? ???? (A), tamoxifen (tmx)? ???? Cdon? ???????? ???? ? ??? ???? ?? ???? ???? ??? ???? ??? ??, Cdon? ??? ??????? ???? ???? ?? ? ? ?? (B).
? ?? ??? ? ???? ??? ??? ?1??? ???? ???? mitochondria ????? ? ? ?? ??? ?????? ????? ???? ??? ????? ???? ??? ??? ?? ????. ??? ??? ?????? ?????? mitochnodria? ??? ??? ??? ??? ???? ?? ???, ??? ??? ???? ?? ??? ??? ???? ??? ??? ??? ?? ???. ?? ?????? PDK1? ?? ??? ??? ??? ?? ??? AKT/S6K pathway? ?????? ????? ?? ?????. ??? ?????? ??? ??? ???? ????, ?????? ????? ?? ???? ???? ??? ?? ???? ???? ??? ?? ??? ??? ??? ??? ? ??? ????.

[??2] ?????? 2?? ??? 26?? ???? ???? ?? ????? ??? ?? ??? ???? typeII ????? ??? ?? ???, ?? ??? ? ??? ??? ????.

[??3] ???? ???????? ???? ????? ????