??? ??? ?? ???, ???K ???? ?? ???? ???? ??? RWD ?? ??
- ??????? ?? ?? ???K ???? ?? ???? ????
- ??? ???(Real-world Data) ?? ??
¡ø (????) ??? ??? ??, ???, ???, ??? ??
??? ??? ?? ???? ??????? ?? ?? ???K ???? ?? ????(?? NOAC)? ???? ?? ???? ??? ???(Real-world data, RWD)? ?? ???? ??? ??? ????? ??? ?? ???? BMC Medicine(IF: 9.3) ???? ????? ???.
NOAC? ??????????? ??? ???? ??? ?? ???? ???? ???? ??? ???? ?????? ?? ???? ??. ????? ???? ???? ????? ?? ?????, ????? ?? ??? ?? ?? ????? ???? ??? ??? ? ??? ?? RWD? ???? ???? ?? ?? ?? ????? ??? ???? ???? ?? ?? RWD ???? ? ??? ?? ????? ??? ????.
?? ???? ?? ??????? ??? ???? 4?? ??? NOAC(????, ?????, ????, ?????)? ?? 5?? ?????????(AMPLIFY, RE-COVER II, Hokusai-VTE, EINSTEIN-DVT, EINSTEIN-PE)? ???? ?? ??? ????????? ???? ????. ????? ??? ??/?? ??, ???? ??? ?? RWD? ???? ??? ??? ?????? ??? ?? NOAC??? ??? ??????? ??? ? ?? ??? ?? ???, ??? ????? ????? ???? ????.
¡ø ??????? ????? ???K ???? ?? ???? ???? ???? ???? ?? ?????? ?? ??? ?? ??
?? ??, 5?? ?????? ??? ?? ????? ?? NOAC? ???? ???? ??????? ??? ?? ????? ?? ??? ???? ???? ???? ??? (RWE vs. RCT: AMPLIFY [0.81, 0.70-0.94 vs. 0.84, 0.60-1.18]; RE-COVER II [0.60, 0.37-0.96 vs. 1.08, 0.64-1.80]; Hokusai-VTE [0.49, 0.31-0.78 vs. 0.89, 0.70-1.13]; EINSTEIN-DVT [0.54, 0.33-0.89 vs. 0.69, 0.44-1.04]; EINSTEIN-PE [0.50, 0.34-0.74 vs. 1.12, 0.75-1.68]). ??, ??????? ?????? ??? ???? ?? ??????, ?? ?? ???? ???? ???? ?? ??? ?? ?? ??? ???? ??? ??? ?? ?? ?? ???? ???? ?? ??? ???? ??? ??? ????.
??? ?? ???? “? ??? ?? ???? ???? ???? ?? ????? RWD? ?? ??? ? ??? ??? ?? ???, ????? ?? ???? ???? ?? ?? RWD ???? ???? ?? ???? ???”? “??? ???? ??? ????? ?? ?? ????????? ??? RWD? ??? ??? ? ??? ????”? ???.
? ????? ??? ?? ???? BMC Medicine (Impact Factor=9.3)? 9? 29?(?) ??? ?????.
¡ù ???: Real-world data emulating randomized controlled trials of non-vitamin K antagonist oral anticoagulants in patients with venous thromboembolism
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