???? ?????? ??? ?? ???, ??? ?????? ??-? ??
- ?? ??? ??-????? ?? ??? ??? ?????? ??? ??
- ?????? ???? ???? ??, ?? ?? ? ?????? ?? ??
¡ø(????) ??? ??? ??, ??? ??????, ??? ????
??? ?? ??? ??? ??, ?? ????, ????, ?????? ? ???? ??? ??? ??????(neuromuscular junction, NMJ*)? ??? ??? ???. ??? ???? ?? ??? ?? ?? ??-? ?? ?? ? NMJ? ??? ???·???? ??? ?? ??? ????.
* NMJ: ???? ??? ???? ???? ??? ??? ??? ? ?? ???
???? ??? ??? ??? ??? 3?? ??? ???? ?? ??? ???? ?? ?? ?????? ???? ?????? ???? ??? ?? ???? ??? ?? ??? ??? ????, ? ?? ??? ?? ?? ??? ??.
??? ????? ???? ?? ??? ??? ?? ???? ????-????, ?????? ???? ???? ??? ????? ?? ? ????? ??? ? ?? ??-?????? ??? ???? ???? ?????.
???? ???? ??? ?????? ? ??? ??? ??? dECM-MA* ?????? ??? ??? ??? ????, ??? ?? ?? ? ???? ??? ??????. ??, ??-?????? ?? ???? ?? ? ??? ??? ????. ???? NMJ ??-? ??? ?? ??? ????? ?? ????? ??(axon) ??? NMJ ??? ????? ??? ? ??? ?????.
* dECM-MA: ???(UV) ??? ??? ??? ???? ???? ?????
???? ??, GelMA* ? ??? ? ?? ?????? ???? ?? ??? ??? ??? ??? ?? ??? ‘rosary shaped structure’ ??-?????? ??? ????? ?????. ??, ??-?????? ?? ???? ??? ???? ????? ???? ??? NMJ ??? ????? ?????.
* GelMA: UV ??? ?? ??? ??? ???? ???
??? ??? “??? ????-????, ?????? ??? ??? ?? ??-?????? ??? ???? ?? ?? ????, ??? ?? ? ????? ?? ??? ??? ?? ? NMJ ??? ????? ??? ? ?? NMJ ??-? ??? ????. ?? ? ???? ??? ????? ???? ??? ?? ??? ?? ??? ??? ????? ??? ????.”?? ???.
?? ?? ??? ??????? ??????????? ?????????????? ????? ??? ???? ??????, ?????? ?? ?? ???? Chemical Engineering Journal(IF: 15.1)*? ????? ?? ?? ???? Applied Physics Reviews(IF: 19.5)? 7? 23?? 8? 14?? ?? ?????.
* ???: Formation of various cell-aggregated structures in the core of hydrogel filament using a microfluidic device and its application as an in vitro neuromuscular junction model (2023. 7. 23.).
** ???: Bioprinting 3D muscle tissue supplemented with endothelial-spheroids for neuromuscular junction model (2023. 8. 14.).
??
