??? ??? ?? ???, ??????? ?? ??? ?? ???? ????? ??
- ???????? ??? ??? ??
[??] ??? ??(????), Nguyen ???(?1??), ??? ???(?2??)
??? ??? ?? ???(?1?? Nguyen ?????)? Ferroptosis ?? ??????? ?? ??? ?? ????(upconversion) ?????? ???? ??????? ??? ??? ???? ?????.
???????(triple-negative breast cancer; TNBC)? ??? ??? ?? ???? ??? ???? ???, ? ????? ??? ? ?? ?? ?? ???? ??? ??. ???? ????? ???? ???? ??? ? ???, ????? ????? ?? ??? ??, ?? ??? ?? ? ???? ???? ??? ?? ??? ???? ???? ??? ??. ??, ???????? ???? ?????? ???? ? ?? ???? ?? ?? ???? ???? ????? ????.
???? ???(Fe2+/Fe3+)? ????? ?? ???? ? ??????? ????? ???? ????? ‘Fenton ??’? ????, ???? ?? ????? ????? ????? ?????(ferroptosis) ???? ???????? ??? ??? ?????, ?? ??? ?? ??? ????? ?????? ???? ?????? ?????.
Fenton ??? ?? ????? ???? ??? ? Fe3+ ??? Fe2+ ???? ??? ???? ??? ????, ? ??? ????(UV)? ????? ????. ??? ????? ??? ?? ??? ??? ?? ?? ?? ??? ?????, ???? 980 nm ?????? 360 nm ?????? ????? ???? ??? ??? ? ?? ??? ?? (Er/Lu)? doping? ????? ?????. ??? Fenton ??? ????? ????? ??????? ??? ?? ??? ???? cisplatin? ????? ????? ????? ??? ?? ??? ??? ???? ?? ?????? ?????.
??? ???? ?????? ??????? ??? ??? ???? ?? ??? ??? ?? ????? ??????, ?? ???(primary tumors)? ??? ?? ????? ?, ????? 2? ???(distant tumors)? ?? ???? ??????? ?????. ????? ???? ??? ??? ?? ???? ??? ferroptosis ??? ?????? ????? ???/???? ????? ??????, ?? ??? ??????? ?? ???? ??? ? ?? ??? ????.
?? ????? ??????? ???????????, ????????? ? ??????????(MRC) ???? ??????, ?? ? ?? ?? ??? ????‘ACS Nano (IF 18.027, JCR ranking 5.8%)’2023? 1?? ?????.
¡ù ???: Amplified Fenton-Based Oxidative Stress Utilizing Ultraviolet Upconversion Luminescence-Fueled Nanoreactors for Apoptosis-Strengthened Ferroptosis Anticancer Therapy
¡ù&²Ô²ú²õ±è;????:
??
