??? ??? ??, ??? ?? ?? ???? ???? ?? ????? ????? ??
- ???? ???? ??? ??? ??
▲ ???(?1??), ???(?2??), ??? ??(????)
??? ??? ?? ???(?1?? ??? ???? ???)? ??? ???? ???? ???? ?? ????? ?????? ???? ???? ??(hypoxic tumors) ???? ?????.
? ??? ???? ???? ???? ?????? ??? ?? ?? ??? ??? ??? ??? ??? ? ?? ??? ??? ??? ??? ??. ?? ??? ?? ??? ?? 30~52mmHg(3.9~6.8%)?? ??? ???? ?? ??? 5mmHg(<0.7%) ???? ?? ???, ??? ??? ??? ???? ??? ??? ??? ???? ?? ?????, ?????? ? ???? ?? ??? ?? ??? ?? ???? ??? ??? ??????. ??? ???? ??? ???? ???? ??? ?? ??? ?????, ????? ?? ?????? ?? ? ?? ??? ???? ?? ?? ? ?? ??? ??? ??? ???? ??.
??? ?? ???? ??? ???? ??? ???? ??? ?? ???? ??? ??? ?????(Hb) ? heme(iron protoporphyrin IX)? ??? ???? (i)?? ??? ? ?? (ii)??? ???? (iii)???? ??? ??? ???? ????(ROS; 1O2)? ??? ? ??, ???? ??? ??(5~6μm)? ?? ???? ????? ?????? ?? ? ?????.
????? ?????? ?? ???, chlorine e6(Ce6) ? 808nm ?????? 660nm ?????? ????? ???? ???? ????? ????. ???? ??? ???? ????? ???? ??? ????? ??? ???? ??? Ce6? ???? ??? ??? ?????? ??? ??? ???? ??? ??. ??? heme? ??? ??? ???? ????? ???? ?? ??? ??? ???? ????? ???? ???? ??? ??? ???? ????? ???? ???? ????? ???? ?? ??? ???? ?? ??? ????? ???? ?? ??? ? ?? ? ?? ??? ????? ?????? ??? ?????.
???? ??? ???? ???? ?? ????? ?????? ????, ???? ?? ? ??? ???? ? ?? ??? ?? ???? ???? ??? ???? ?? ??? ??? ????? ?? ?????? ???. ????? in situ ?? ??? ??? ??? ?????(5–6μm) ??? ???? ????? ?? ???? ??? ???? ??? ??? ????.
?? ????? ??????? ??????????? ? ??????????(MRC) ???? ??????, ???? ?? ??? ???? Bioactive Materials(IF: 16.874, JCR ranking 2.0%) 2023? 4??? ?????.
※ ???: Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat, oxygen and reactive oxygen species for suppressing hypoxic tumors
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