??? ??? ?? ???,
????? ??? ??? ?? ??? ???
- Presenilin-1 ????? ??????? ??? ?? ??
- ??? ????? ??? ?? ??
??????(?? ???) ??? ??? ?? ???(?1?? ??? ????)? ??? ????? ??? ?? ???? ??? Presenilin-1 ?????? ????? ??????? ??? ??? ????? ???.
? ??? ?????? ????? ?? ????? ????? ?? ?? ???? ????? ??? Presenilin-1? ??????? ??? ??? ??? ???? ????? ??? ???? ?????.
???? ???????? ?? ?? ???? ?? ??? Presenilin-1 ????(A431E, E280A, H163R, M146V, Δexon9)? ????? ???-?????? ??? ?????? ??? ???.
?? Presenilin-1 ????(M146V) ??(knock-in: KI) ???? ??? ??? ?? ?? ??? ?? PS1M146V ????? ATL2? ??? ??????? ???? ??????? ??? ?????? ?????? ??? ?????, ATL2? ???? ????? ??? ????? ??? ?? ??? ???? ?? ????.
??? ??? “????? ???? ?????? ????? ???-?????? ??? ??? ?? ???(Atl2)? ?? ??”?? “? ?? ???? ???? ???? ????? ??? ??? ????? ??? ??? ??? ?”??? ???.
? ??? ??????? ???? ????????? ?????????? ??????(MRC) ?? ???? ??????, ?? ?? ??? ???? Theranostics(IF 11.556, JCR ranking 6.4%)? ?? 9? ?????.
※ ??? : Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function
[??1]Presenilin-1 ????? ?????? ??? ??? ??
??? ???????? ?? ?? ???? ????? ????? 1 ???? (A431E, E280A, H163R, M146V, and Δexon9)? ????? ER-?????? ??? ?????? ??????? ??? (membrane potential)? ????? ????? (reactive oxygen species: ROS)? ??? ?????. PS1M146V ????? ATL2 ??? ??????? ER? ??????? ??? ?????? ?????. ATL2? ???? ????? ??? ????? ??? ?? ??? ?????? ???.
??
